Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8
Supplement Facts
Serving Size: 1 Fish Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Cholesterol
<5 mg
1%
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Fish Oil Concentrate
1.2 g (1,200 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
600 mg
†
Docosahexaenoic Acid (DHA)
300 mg
†
Top Medical Research Studies
9
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Omega-3 reduces cardiovascular risk
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
8
We explored the impact of eicosapentaenoic acid (EPA) on heart health by studying mice on a high-fat diet. Those supplemented with EPA showed a significant reduction in atrial fibrillation compared to those without. While 100% of the high-fat diet mice developed atrial fibrillation, only 50% of those receiving EPA did, and their episodes were shorter.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Read More
Most Useful Reviews
7.5
Supports cardiovascular system
11 people found this helpful
This omega with vitamin D in a single capsule is excellent! The quality is assured by the reputable brand Now Foods. The ingredients include fish oil (anchovy) and fish gelatin. I regularly give this omega to my parents, aged 67, at a daily dose of one capsule with meals. The cost-effective packaging provides 180 capsules, lasting a long time. I recommend it for supporting cardiovascular health.
Read More
9
Miraculous health benefits
8 people found this helpful
This Omega-3 has an excellent EPA and DPA ratio, plus vitamin D. I've taken it consistently for a year and a half, only from NOW, and plan to continue. Remarkably, I haven’t suffered from a cold for that time, and my chronic sinusitis has disappeared, which is miraculous for me! Overall, it's made a significant difference in my health and I have no hesitation in recommending it.
Read More
9
Stable lipid profile
1 people found this helpful
A must-have! I have been taking this consistently since March 2020. After a comprehensive health examination in February 2021, my lipid profile results were normal, and my cardiovascular system is healthy. The quality of the raw materials from Now Foods is impressive, especially with the added vitamin D. I have been pleased with all their products and exclusively purchase supplements from IHerb due to their reliability and quality.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.7
- All Researches
9
Omega-3 reduces cardiovascular risk
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
9
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Read More
9
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
8
This study examined how different fatty acids affect heart health, particularly focusing on long-chain acylcarnitines. We found that saturated and monounsaturated acylcarnitines, especially one type called trans-elaidoylcarnitine, can significantly harm heart function and cell viability.
On the other hand, omega-3 derived acylcarnitines like eicosapentaenoylcarnitine and docosahexaenoylcarnitine showed minimal negative effects. In fact, they did not impair heart function or cell viability, suggesting that omega-3 fish oil might be a safer option for people with heart issues compared to other fatty acid sources.
On the other hand, omega-3 derived acylcarnitines like eicosapentaenoylcarnitine and docosahexaenoylcarnitine showed minimal negative effects. In fact, they did not impair heart function or cell viability, suggesting that omega-3 fish oil might be a safer option for people with heart issues compared to other fatty acid sources.
Read More
8
We explored the impact of eicosapentaenoic acid (EPA) on heart health by studying mice on a high-fat diet. Those supplemented with EPA showed a significant reduction in atrial fibrillation compared to those without. While 100% of the high-fat diet mice developed atrial fibrillation, only 50% of those receiving EPA did, and their episodes were shorter.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports cardiovascular system
11 people found this helpful
This omega with vitamin D in a single capsule is excellent! The quality is assured by the reputable brand Now Foods. The ingredients include fish oil (anchovy) and fish gelatin. I regularly give this omega to my parents, aged 67, at a daily dose of one capsule with meals. The cost-effective packaging provides 180 capsules, lasting a long time. I recommend it for supporting cardiovascular health.
Read More
9
Miraculous health benefits
8 people found this helpful
This Omega-3 has an excellent EPA and DPA ratio, plus vitamin D. I've taken it consistently for a year and a half, only from NOW, and plan to continue. Remarkably, I haven’t suffered from a cold for that time, and my chronic sinusitis has disappeared, which is miraculous for me! Overall, it's made a significant difference in my health and I have no hesitation in recommending it.
Read More
9
Stable lipid profile
1 people found this helpful
A must-have! I have been taking this consistently since March 2020. After a comprehensive health examination in February 2021, my lipid profile results were normal, and my cardiovascular system is healthy. The quality of the raw materials from Now Foods is impressive, especially with the added vitamin D. I have been pleased with all their products and exclusively purchase supplements from IHerb due to their reliability and quality.
Read More
7.5
Lowering cholesterol
This omega offers a good price-quality ratio, with an excellent balance of EPA and DHA, supporting the cardiovascular system and playing a vital role in maintaining health and lowering cholesterol levels.
Read More
8
Convenient nutrient source
28 people found this helpful
The convenience of having 900 mg of EPA + DHA along with a recommended vitamin D dosage in one capsule is remarkable. This supplement addresses essential nutrients critical for health. I advocate for its usage on a global scale to prevent numerous diseases. Regular testing for vitamin D levels helps determine the appropriate dosage and adjust intake as needed. Vitamin D3 is pivotal, but the cumulative effects should not be overlooked!
Read More
Frequently Asked Questions
9
Stable lipid profile
1 people found this helpful
A must-have! I have been taking this consistently since March 2020. After a comprehensive health examination in February 2021, my lipid profile results were normal, and my cardiovascular system is healthy. The quality of the raw materials from Now Foods is impressive, especially with the added vitamin D. I have been pleased with all their products and exclusively purchase supplements from IHerb due to their reliability and quality.
7.5
Improved sleep quality
3 people found this helpful
Quality product! This product contains a high concentration of EPA and DHA (300 DHA and 600 EPA) omega-3 fatty acids, alongside vitamin D3. The capsules are easy to swallow, with no smell or aftertaste. I have been using omega-3 in the morning combined with Q10 for better cardiovascular system function for several years. I take it for three months followed by a month’s break. Previously, I experienced issues with sleep and fatigue, but these issues have now disappeared. The product works effectively. I highly recommend it!
9
Miraculous health benefits
8 people found this helpful
This Omega-3 has an excellent EPA and DPA ratio, plus vitamin D. I've taken it consistently for a year and a half, only from NOW, and plan to continue. Remarkably, I haven’t suffered from a cold for that time, and my chronic sinusitis has disappeared, which is miraculous for me! Overall, it's made a significant difference in my health and I have no hesitation in recommending it.
8
Effective inflammation control
1 people found this helpful
This fish oil is potent for managing cardiovascular issues and has anti-inflammatory properties. The taste is acceptable, and I've noticed an improvement in my cholesterol levels after health checks. This high-dose omega is well worth the purchase.
8
Convenient nutrient source
28 people found this helpful
The convenience of having 900 mg of EPA + DHA along with a recommended vitamin D dosage in one capsule is remarkable. This supplement addresses essential nutrients critical for health. I advocate for its usage on a global scale to prevent numerous diseases. Regular testing for vitamin D levels helps determine the appropriate dosage and adjust intake as needed. Vitamin D3 is pivotal, but the cumulative effects should not be overlooked!
7.5
Supports cardiovascular system
11 people found this helpful
This omega with vitamin D in a single capsule is excellent! The quality is assured by the reputable brand Now Foods. The ingredients include fish oil (anchovy) and fish gelatin. I regularly give this omega to my parents, aged 67, at a daily dose of one capsule with meals. The cost-effective packaging provides 180 capsules, lasting a long time. I recommend it for supporting cardiovascular health.
8
We explored the impact of eicosapentaenoic acid (EPA) on heart health by studying mice on a high-fat diet. Those supplemented with EPA showed a significant reduction in atrial fibrillation compared to those without. While 100% of the high-fat diet mice developed atrial fibrillation, only 50% of those receiving EPA did, and their episodes were shorter.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
Our findings suggest that including EPA in the diet can help improve heart function and reduce irregular heart rhythms linked to high-fat diets.
8
Diet and fish oil improve heart health
We explored how dietary changes, particularly the MoKaRi diet, can impact cardiovascular health. In a 20-week study with 65 participants, individualized meal plans were combined with fish oil supplements to assess their effects on various cardiometabolic risk factors.
The results showcased significant reductions in cholesterol levels, body weight, and other critical indicators. Notably, those who incorporated fish oil saw even greater improvements in weight loss and blood sugar levels. This research suggests that pairing a healthy diet with fish oil can enhance cardiovascular outcomes.
The results showcased significant reductions in cholesterol levels, body weight, and other critical indicators. Notably, those who incorporated fish oil saw even greater improvements in weight loss and blood sugar levels. This research suggests that pairing a healthy diet with fish oil can enhance cardiovascular outcomes.
8
We investigated the role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing cardiovascular disease through a meta-analysis of randomized clinical trials.
Our findings indicated that prescription medications containing PUFAs may reduce the risk of cardiovascular events, including heart attacks and cardiac death.
However, while these results contribute valuable insights, the overall cardioprotective effects remain a topic of debate.
This research helps clarify how PUFA medications fit into heart health strategies.
Our findings indicated that prescription medications containing PUFAs may reduce the risk of cardiovascular events, including heart attacks and cardiac death.
However, while these results contribute valuable insights, the overall cardioprotective effects remain a topic of debate.
This research helps clarify how PUFA medications fit into heart health strategies.
9
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
9
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
References
- Liepinsh E, Gukalova B, Krims-Davis K, Kuka J, Leduskrasta A, et al. EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines. Biofactors. 2025;51:e70014. 10.1002/biof.70014
- Medoro A, Graziano F, Cardinale G, Voccola S, Zotti T, et al. The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation. Lipids Health Dis. 2025;24:102. 10.1186/s12944-025-02513-w
- Horii K, Ono K, Sumi T, Higashihara M, Zaima N, et al. Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice. J Physiol Sci. 2025;75:100014. 10.1016/j.jphyss.2025.100014
- Dawczynski C, Drobner T, Weidauer T, Schlattmann P, Kiehntopf M, et al. Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study. Lipids Health Dis. 2025;24:88. 10.1186/s12944-025-02500-1
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
- Mao Q, Tian X, Wang X, Xu H, Zhang Y, et al. Global burden of cardiovascular diseases attributable to diet low in seafood omega-3 fatty acids from 1990~2021 and forecasting the future trends: A population-based study. PLoS One. 2025;20:e0316767. 10.1371/journal.pone.0316767
- Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. 10.1016/j.advnut.2025.100366
- Hemmati R, Bahrami Zanjanbar D, Shishesaz MI, Soleimani A, Yari T. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial. J Complement Integr Med. 2025;22:173. 10.1515/jcim-2024-0427
- Wang Y, Wu G, Wang Y, Rehman A, Yu L, et al. Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases. Food Chem. 2025;470:142498. 10.1016/j.foodchem.2024.142498
- Dong S, Wang Y, Bian J, Chen H, Dong J, et al. The effect of omega-3 Polyunsaturated Fatty Acid (PUFA) prescription preparations on the prevention of clinical cardiovascular disease: a meta-analysis of RCTs. Nutr J. 2024;23:157. 10.1186/s12937-024-01051-y
- Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. 10.1016/j.mayocp.2024.08.007
- Brosolo G, Da Porto A, Marcante S, Capilupi F, Bertin N, et al. The role for ω-3 polyunsaturated and short chain fatty acids in hypertension: An updated view on the interaction with gut microbiota. Eur J Pharmacol. 2024;985:177107. 10.1016/j.ejphar.2024.177107
- Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. 10.1017/S0007114524002708
- Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. 10.1038/s44319-024-00271-x
- Li ZH, Song WQ, Qiu CS, Li HM, Tang XL, et al. Fish oil supplementation, genetic susceptibility and risk of new-onset hypertension. Prev Med. 2024;189:108152. 10.1016/j.ypmed.2024.108152
